Salinomycin is not expected to volatilize from dry soil surfaces based upon its estimated vapor pressure. Salinomycin was degraded 50-70% in soil in 7 day aerobic studies, 20-25% was attributed to abiotic reactions and the remaining portion was considered biodegradation.

Treatment of 5 mg/kg salinomycin in mice implanted with SUM159 human breast cancer cells inhibits mammary tumor growth and induces increased epithelial

Salinomycin sodium salt. Salinomycin (sodium salt) UNII-92UOD3BMEK. 55721-31-8 Type A medicated articles containing 30 or 60 grams of salinomycin activity per pound (as salinomycin sodium biomass). Salinomycin is a membrane ionophore, which shows affinity for alkali ions, preferentially for potassium ions. 2 Salinomycin eases the ion flux through cytoplasmic membrane and the mitochondrial membrane. Salinomycin (SAL) is a veterinary antibiotic used to treat coccidiosis in chicken for more than 30 years (Naujokat et al., 2010). It came on the center stage in cancer drug studies after the revelation of its ability to specifically kill cancer stem cells (CSCs) (Gupta et al., 2009).

Salinomycin

Analytical method (1) For the quantification of salinomycin in … Salinomycin reduces the proportion of cancer stem cells(CSC) by >100-fold relative to paclitaxel, a commonly used breast cancer chemotherapeutic drug. Millipore Salinomycin S4526-5MG | Sigma-Aldrich. Search term: "Salinomycin S4526-5MG". Compare Products: Select up to 4 products.

This refocused its importance for treatment of human cancers. Salinomycin sodium | C42H69NaO11 | CID 23703990 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological 2017-03-28 · Salinomycin is a potent inhibitor of P-gp, which makes cells sensitive to chemotherapeutic drugs.

salinomycin/kg salinomycin sodium. — ≤ 10 g 20- desoxysalinomycin/kg salinomycin sodium. — ≤ 10 g 18,19- dihydrosalinomycin/kg salinomycin sodium. — ≤ 10 g methylated salinomycin/kg salinomycin sodium. Analytical method (1) For the quantification of salinomycin in …

Salinomycin is the key compound in the pharmaceutical company Verastem's efforts to produce an anti-cancer-stem-cell drug. Use in agriculture. Salinomycin is used in chicken feed as a coccidiostat.

Salinomycin (Procoxacin) is an antibacterial and coccidiostat ionophore therapeutic agent.

The ionic affinity of salinomycin is predominantly to sodium and potassium ions, and its mode of action and cellular effects are similar to those of monensin.87. Salinomycin, traditionally used as an anti-coccidial drug, has recently been shown to possess anti-cancer and anti-cancer stem cell (CSC) effects, as well as activities to overcome multi-drug resistance based on studies using human cancer cell lines, xenograft mice, and in case reports involving cancer patients in pilot clinical trials. Salinomycin (71; R = H), obtained by culturing a strain of Streptomyces albus 〈72JAP(K)7225392〉, and narasin (71; R = Me), 4-(S)-methylsalinomycin, the main component of a polyether complex produced by Streptomyces aurofaciens 〈78JAN1〉 are now used to prevent coccidiosis, particularly in broiler chickens. Salinomycin reduces the proportion of cancer stem cells(CSC) by >100-fold relative to paclitaxel, a commonly used breast cancer chemotherapeutic drug. Millipore Substance identity Substance identity. The ‘Substance identity’ section is calculated from substance identification information from all ECHA databases. The substance identifiers displayed in the InfoCard are the best available substance name, EC number, CAS number and/or the molecular and structural formulas.

Salinomycin in är endast tillåtet i vissa fjäderfäfoder och kan vara skadligt för andra djurslag. Salinomycin is an ionophore, also marketed as a coccidiostat, which is related more closely to monensin than is lasalocid. The ionic affinity of salinomycin is predominantly to sodium and potassium ions, and its mode of action and cellular effects are similar to those of monensin.87.
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Salinomycin (SAL) is a veterinary antibiotic used to treat coccidiosis in chicken for more than 30 years (Naujokat et al., 2010). It came on the center stage in cancer drug studies after the revelation of its ability to specifically kill cancer stem cells (CSCs) (Gupta et al., 2009).

Salinomycin fails to induce apoptosis in normal human peripheral CD4+ T lymphocytes. 2011-06-02 · Salinomycin is a polyether antibiotic with properties of an ionophore, which is commonly used as cocciodiostatic drug and has been shown to be highly effective in the elimination of cancer stem Salinomycin sodium, Sodium salinomycin: SMILES: CCC(C1CCC(C(O1)C(C)C(C(C)C(=O)C(CC)C2C(CC(C3(O2)C=CC(C4(O3)CCC(O4)(C)C5CCC(C(O5)C)(CC)O)O)C)C)O)C)C(=O)O.[Na+] Storage: Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of Översättnings-API; Om MyMemory; Logga in Salinomycin analogs: Mechanistic probes and structure–activity relationships against cancer stem cells.
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Histopathologically, salinomycin induces severe myocardial and skeletal muscle lesions showing myocardial hyperemia, myocardial fiber degeneration and myocardial mitochondria damage. In cases of higher mortality, histopathology of skeletal muscles showed severe muscle degeneration and necrosis with myocardial fragmentation, oedema and fat infiltration, suggesting cardiac failure is probably …

1549 - 7 Dec 2011 Very recently, it has been shown that it is possible to selectively kill breast cancer stem cells using the ionophore antibiotic, salinomycin. 16 May 2017 Salinomycin kills cancer stem cells by sequestering iron in lysosomes · Abstract. Cancer stem cells (CSCs) represent a subset of cells within 10 Dec 2018 Salinomycin is a monocarboxylic polyether ionophore that has been discovered in high throughput screening as a potential anti-cancer drug 11 Jun 2020 A high-throughput study in 2009 identified the potential of salinomycin to kill stem cell-like breast cancer cells and significantly reduce their tumor Treatment of 5 mg/kg salinomycin in mice implanted with SUM159 human breast cancer cells inhibits mammary tumor growth and induces increased epithelial Unfortunately Salinomycin sodium salt (Cat. No. 3637) has been withdrawn from sale for commercial reasons. Salinomycin is an antibacterial and coccidiostat ionophore therapeutic drug.

Salinomycin sodium salt. Catalog # 3637. Datasheet / COA / SDS. Antibiotics Small Molecule. Discontinued Product. 3637 has been discontinued. View all

Salinomycin, traditionally used as an anti-coccidial drug, has recently been shown to possess anti-cancer and anti-cancer stem cell (CSC) effects, as well as activities to overcome multi-drug resistance based on studies using human cancer cell lines, xenograft mice, and in case reports involving cancer patients in pilot clinical trials. Salinomycin (71; R = H), obtained by culturing a strain of Streptomyces albus 〈72JAP(K)7225392〉, and narasin (71; R = Me), 4-(S)-methylsalinomycin, the main component of a polyether complex produced by Streptomyces aurofaciens 〈78JAN1〉 are now used to prevent coccidiosis, particularly in broiler chickens. Salinomycin reduces the proportion of cancer stem cells(CSC) by >100-fold relative to paclitaxel, a commonly used breast cancer chemotherapeutic drug. Millipore Substance identity Substance identity. The ‘Substance identity’ section is calculated from substance identification information from all ECHA databases. The substance identifiers displayed in the InfoCard are the best available substance name, EC number, CAS number and/or the molecular and structural formulas.

However, its biosynthesis had only been studied by feeding experiments with isotope-labeled precursors. A strategy with degenerate primers based on the polyether-specific epoxidase sequences was successfully developed to clone the salinomycin gene cluster. Using this Salinomycin is able to effectively eliminate CSCs and to induce partial clinical regression of heavily pretreated and therapy-resistant cancers. It has also been demonstrated as a positive ionotropic and chronotropic agent that increased cardiac output, left ventricular systolic pressure, heart rate, mean arterial pressure, coronary artery vasodilatation and blood flow, and plasma 2019-02-14 · Objectives Salinomycin is a polyether antibiotic with selective activity against human cancer stem cells. The impact of salinomycin on patient-derived primary human colorectal cancer cells has not been investigated so far. Thus, here we aimed to investigate the activity of salinomycin against tumor initiating cells isolated from patients with colorectal cancer. Methods Primary tumor-initiating Salinomycin is an antibiotic isolated from Streptomyces albus that selectively kills cancer stem cells (CSCs).